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The Company of Biologists uses the surplus it generates for the benefit of biology and the biological community. We support through grant funding:

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Intranasal insulin has been shown to improve memory in both humans and mice. However, in most cases less than 0.05% of insulin delivered via the intranasal route actually reaches the brain. Buccal epithelium is routinely used as an?in vitro?model for investigating peptide uptake, but Elizabeth Rhea, a postdoctoral fellow in the Department of Medicine at the University of Washington, USA, wished to investigate its potential as a model for screening enhancers of intranasal insulin delivery.?A Travelling Fellowship from Disease Models & Mechanisms allowed Elizabeth to travel to Joseph Nicolazzo’s lab at Monash University in Melbourne, Australia. There, Elizabeth hoped to utilise the expertise of the Nicolazzo lab in exploiting the buccal mucosa for absorption of therapeutics, and to develop a method to determine if commonly used enhancers are able to increase insulin transfer across the epithelium.

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